Azania Mosaka will be taking over Anele Mdoda's Steyn City studio couch to host the weekday talk show, while the regular host is on a break.
SABC3 says the Mdoda will taking some time off "to get some much-needed rest and time away from the hustle and bustle of Johannesburg with her family".
Mdoda will host 12 episodes starting next Tuesday, 17 April, until 27 April. Mosaka will return to screens on 30 April.
In an interview with SowetanLive,Mosaka said she jumped at the opportunity.
After a protracted hiatus from TV in favour of the radio mic, she said she was looking forward to getting back in front of the cameras after so many years.
"I haven't been on TV in a long time. Funnily enough, at the start of the year, one of the things lingering with me was that maybe it's time to get in there. I was open to it if it came along," she was quoted saying.
"So when [production house] Cheeky Media and the SABC gave me the thumbs-up, I was happy. I didn't realise how much I missed television as a medium. I wanted the immediate gratification that radio gave me, but I missed looking into the camera and doing my thing."
Mosaka promises to bring her personal flair to the show.
Real Talk with Anele airs weekdays on SABC3 from 6pm-7pm.